Methylene tetrahydrofolate reductase (MTHFR)

Methylene tetrahydrofolate reductase (MTHFR)

Methylene Tetrahydrofolate Reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Natural variation in this gene is common in healthy people. Although some variants have been reported to influence susceptibility […]

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MTHFR

The full name of the MTHFR gene is “methylenetetrahydrofolate reductase” The protein encoded by this gene is an enzyme that catalyzes the reduction of methylenetetrahydrofolate to methyltetrahydrofolate,  This enzyme is essential for the homeostasis and normal metabolism of intracellular folate. In humans, MTHFR is located on the chromosome 1. It is expressed in various tissues

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