The symptoms you describe—a lytic lesion with aggressive features, intense pain, and rapid swelling—require medical evaluation and a definitive diagnosis. A biopsy is the only way to determine whether this is Langerhans Cell Histiocytosis (LCH), osteosarcoma, tuberculosis, or another condition. Each of these has a completely different treatment pathway.
Regarding your specific concerns:
Anesthesia safety: Modern anesthesia is very safe, and serious complications are extremely rare. Your anesthesiologist will review your heart and overall health before any procedure.
Biopsy procedure: A bone biopsy can often be performed with a needle under local anesthetic and imaging guidance (CT or ultrasound), which is minimally invasive and does not always require general anesthesia. You can discuss your specific fears with the interventional radiologist.
Your TB hypothesis: Bone tuberculosis can indeed present as a lytic lesion with pain and swelling, and it can occur without systemic symptoms. If TB is confirmed, it can be treated with anti-tubercular medication along with the Rife Tuberculosis Group. The fact that you have Type 1 diabetes is an important factor. In diabetic patients, infections like TB can be more difficult to diagnose and may present differently . Your previous history of a bone lesion and a positive TB test may also point to Bone tuberculosis.
These tests should be done to identify the problem .
There is a group for Tuberculosis for the RDPV3:
Tuberculosis: 0.14, 7.5, 30.16, 67.5, 96.5, 275.16, 434.16, 527, 663.71, 752.7
